“Furthermore, the study of molecular docking also indicated that zonisamide could strongly bind to the site I (subdomain IIA) of HSA mainly by hydrophobic interaction and there were hydrogen bond interactions between this drug and HSA, also known as the warfarin binding site.”
“The … of ZNS … HSA caused strong fluorescence quenching of HSA through static quenching mechanism, hydrogen bonds and van der Waals contacts are the major forces in the … ZNS complex and the process of the binding of ZNS with HSA was driven by enthalpy (ΔH=-193.442 kJ mol(-1)).”