Possible Interaction: Zinc Cation and Manganese Cation (2+)

“In vitro growth analyses show that extracellular Zn(II ) is able to inhibit Mn(II) intracellular accumulation with little effect on intracellular Zn(II).”

“S. pneumoniae infection in vivo elicits massive elevation of the Zn(II):Mn(II) ratio and, in vitro, these Zn(II):Mn(II) ratios inhibited growth due to Mn(II) starvation, resulting in heightened sensitivity to oxidative stress and polymorphonuclear leucocyte killing.”

“ Zn(II ) ions inhibit the initial velocity of Mn(II) uptake, increase total Mn(II) accumulated, but do not alter the rate or extent Mn(II) efflux.”

“It is known that, in the absence of α-lactalbumin, Zn(II ) competes with Mn(II ) for the same binding site(s) in galactosyltransferase, resulting in an increase in the apparent Michaelis constant,Km(app), for Mn(II)-activation of N-acetyllactosamine synthesis.”

“Mg(II), Co(II), and Zn(II ) can displace Mn(II ) from manganese-tubulin, but Ca(II) cannot.”

“Furthermore, the presence of Zn(II) suppressed expression of the response regulator Spo0F, but not of sensor histidine kinases KinA-… induction under biofilm-inducing conditions, leading to repression of transcription of operons epsA-O and tapA-sigW-tasA. Addition of Zn(II) … Mn(II) level by competing …(II) uptake.”

“Both the Zn(II ) in the i site and the Mg(II) in i + 1 are displaced by Mn(II).”