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“Some of the molecules specialized in the handling of alkaline earth (Mg2+, Ca2+) and transition metal ions (e.g. Zn2+ , Cu2+/+, Fe3+/2+) should be particularly sensitive to the presence of Cd2+ , because they enclose cationic sites to which the toxic metal can bind.”
“20 times enhancement in fluorescence intensity on interaction with Zn2+ , due to snapping of photoinduced electron transfer (PET) process, which is selective over metal ions - Na+, K+, Ca2+, Ni2+, Cu2+, Cd2+ , Hg2+ and Pb2+.”
“Addition of Zn2+ (10 and 100 μmol/L) reduced Cd2+ -mediated cytotoxicity.”
“In addition, expression of caspase 9 was lower in Cd2+ (5 μmol/L)-treated PC12 cells when co-treated with Zn2+ (2 and 5 μmol/L).”
“These findings suggest that the effective inhibition of Cd2+ -induced apoptosis in PC12 cells by Zn2+ might be due to suppression of mitochondrial apoptosis pathway and inhibition of Cd2+-induced production of reactive oxygen species.”
“Mn2+, Cu2+, and Zn2+ were found to be competitive inhibitors of the holoenzyme with respect to substrate and Cd2+ and Co2+ were noncompetitive inhibitors.”
Protein science : a publication of the Protein Society • 1997 | View Paper
“This result appears related to the metal-chelating property of 1,10-phenanthroline, since the inhibition was decreased by addition of Zn2+ and Cd2+ , but not by Ca2+, Ba2+, or Mg2+ for which the affinity of the chelator is low.”
The Journal of biological chemistry • 1987 | View Paper
“These isoforms were reacted with different metal ions; Cd2+ and Ni2+ severely inhibited the enzyme activity, while Mg2+, Zn2+ , Cd2+, Fe2+ Cu2+, and Ni2+ inhibited to a lesser extent, which clearly demonstrated that variations in enzyme activity were due to their differential binding affinity of metal ions.”
“Glutathione concentrations were affected only upon exposure to Cd (85% increase) or the combination of Cd with Zn (65% decrease), relative to the control experiment.”
“Ratios of phytochelatins to glutathione indicated a pronounced metal stress in response to exposures to Cu or Cd combined with Zn.”
“The simultaneous exposure to Zn and Cd led to an antagonistic effect on phytochelatin production, which was probably caused by metal competition for cellular binding sites.”