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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Zidovudine and Levocarnitine

supplement:

Levocarnitine

Research Papers that Mention the Interaction

Apoptotic CD4 and CD8 cells, lymphocytes with disrupted mitochondrial membrane potential, and lymphocytes undergoing oxidant stress were greatly reduced in subjects treated with AZT and DDI plus L-carnitine compared with those who did not receive L-carnitine.
Antioxidants & redox signaling  •  2002  |  View Paper
This mechanism can be proposed to explain the protective effects of L-carnitine against adriamycin cardiotoxicity, ammonium acetate and zidovudine-induced mitochondrial ultrastructural and functional alterations.
Drugs under experimental and clinical research  •  2001  |  View Paper
On … hand l-carnitine , in association with the mitochondrial cardiolipins, … due to continued prescription of drugs [ AZT (zidovudine), ddl (didanoside), or ddC (zalcitabine)], and the redox couple of α-lipoic-dihydrolipoic acid prevents … of the reactive oxygen species that trigger apoptosis of infected cells, with sphingomyelin breakdown to ceramides.
Lipids  •  2007  |  View Paper
Because L-carnitine plays a major role in the transport of long chain fatty acids across … mitochondrial membrane and facilitates the beta-oxidation of fatty acids, we examined the effect of L-carnitine in preventing … effect of AZT on the mitochondria and the myotubes … human muscle in tissue culture.
One-third of the flasks were treated with AZT alone, another third with AZT plus L-carnitine and another third were untreated.
Laboratory investigation; a journal of technical methods and pathology  •  1994  |  View Paper
L-carnitine … AZT treatment continued for 3 more weeks, the number of myotubes increased from 3.3 +/- 0.74 to 6.87 +/- 1.35; the absolute … < 0.05); and the Vvi of the lipid droplets decreased from 5.06 +/- 1.44 to 2.72 +/- 0.72 (p < 0.05).
Laboratory investigation; a journal of technical methods and pathology  •  1994  |  View Paper
On the other hand, compounds such as verapamil and AZT were both able to inhibit both the skeletal muscle and the cardiac uptake of L-carnitine.
Biochimie  •  2008  |  View Paper
In C2C12 cells, the supplementation of L-carnitine prevented the effects of zidovudine and restored the normal cell growth.
We also demonstrated that zidovudine inhibited the L-carnitine transporter.
Biochemical pharmacology  •  2003  |  View Paper