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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Zalcitabine
supplement:
Levocarnitine
Research Papers that Mention the Interaction
“The uptake of ddCTP and ddCDP-choline by mitochondria is inhibited by 3.0 mM l-carnitine in the cell-free system investigated; when added to U937 cells grown in the presence of 0.25 microM ddCyd, 3.0 mM l-carnitine partially abrogated the mitochondrial toxicity of ddCyd.”
Metabolism, mitochondrial uptake and toxicity of 2', 3'-dideoxycytidine.“On … hand l-carnitine , in association with the mitochondrial cardiolipins, inhibits myopathy due … prescription of drugs [AZT (zidovudine), ddl (didanoside), or ddC (zalcitabine)], and the redox couple of α-lipoic-dihydrolipoic acid prevents production of the … oxygen species that trigger apoptosis of infected cells, with sphingomyelin breakdown to ceramides.”
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