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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Yohimbine
drug:
Milnacipran
Research Papers that Mention the Interaction
“This effect of milnacipran was reversed by yohimbine , metergoline, katanserin and ondansetron, but not prazosin.”
The role of spinal serotonin receptor and alpha adrenoceptor on the antiallodynic effects induced by intrathecal milnacipran in chronic constriction injury rats.“The antiallodynic effect of 30 &mgr;g of milnacipran was attenuated by intrathecal coadministration of 30 &mgr;g of yohimbine , an α2-adrenoceptor antagonist, 30 &mgr;g of methysergide, a serotonin receptor antagonist, or 30 &mgr;g of atropine, a muscarinic receptor antagonist (P < 0.01, respectively).”
“Behavioral signs (locomotion and rearing) were markedly observed following milnacipran alone or combined administration of milnacipran and yohimbine.”
“Combined administration of yohimbine (2 mg/kg, s.c.),?alpha(2)-adrenoceptor?antagonist, at 2 h after milnacipran (60 mg/kg, s.c.)”
“These results may suggest … with the treatment of yohimbine … milnacipran results from negative feedback following the blockade of alpha(2)-adrenoceptors achieved with yohimbine, and that WAY100635 but not NAN-… in the dorsal raphe nucleus to control levels by preventing the activation for the presynaptic 5-HT(1A) autoreceptor.”
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