Possible Interaction: Yohimbine and Colforsin

“However, in the presence of the α2-adrenoceptor antagonist yohimbine (0.03 µmol/l) both forskolin and IBMx increased the stimulation-induced transmitter overflow by 49% and 141%, respectively (compared to yohimbine 0.03 µmol/l).”

“Propranolol (0.1 µmol/l) that did not produce any effect on noradrenaline release markedly reduced the facilitatory response induced by forskolin in the presence of yohimbine.”

“Treatment with phentolamine, yohimbine or idazoxan suppressed the IPSPs before and after potentiation by forskolin , suggesting that the IPSPs were mediated by release of norepinephrine acting at alpha 2-adrenoceptors.”

“7 The enhancing effects of yohimbine (1 μ m) with tetraethylammonium (2 mm), 8‐bromo cyclic AMP (1 mm), or forskolin (25 μm) were additive, but not those of yohimbine (1 μm) with prazosin (10 μm), 4‐aminopyridine (0.5 mm), or 3‐isobutyl‐1‐methylxanthine (4 mm).”