Possible Interaction: Xylitol and Xylose

“ Xylitol accumulation was inhibited by the inclusion of an aldose reductase inhibitor in the xylose-containing medium.”

“ Xylitol inhibited formation of precipitates also in the presence of D-xylose , dextrans, and starch.”

“The level of xylitol attained in the presence of 10 mM xylose was 25.7 +/- 2.4 mmoles/Kg.”

“Interestingly, concomitant with xylose consumption, xylitol synthesis was noticed, reaching a maximum concentration of 7.64g/L, with a yield on xylose of 0.52g/g.”

“Optimized conditions (urea 1.5 g/L, KH2PO4 1.9 g/L, xylose 55 g/L, pH 6.7) enhanced xylitol yield by 32% and xylose consumption by twofold over those of basal media.”

“The yield of xylitol from consumed xylose was over 98% (0.99g/g).”

“ABSTRACT The recombinant xylose-fermenting Saccharomyces cerevisiae strain harboring xylose reductase (XR) and xylitol dehydrogenase (XDH) from Scheffersomyces stipitis requires NADPH and NAD+, creates cofactor imbalance, and causes xylitol accumulation during growth on d-xylose.”

“In addition, it was demonstrated that xylitol in the medium exhibits a concentration-dependent inhibition effect on the ethanol production from xylose with the yeast harboring the XI-based xylose metabolic pathway.”

“On the other hand, the pH increase favored both the xylitol yield (YP/S) and volumetric productivity (QP), and the xylose concentration increase positively influenced the xylitol concentration.”

“Xylose fermentation is greatly inhibited at high pH. The yields of ethanol and xylitol are greatly influenced by the initial concentration of xylose.”