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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Warfarin and Serum Albumin, Human

Research Papers that Mention the Interaction

An in vitro experiment showed that the binding affinity to warfarin became stronger when HSA was glycated, while HSA binding to heparin was not significantly influenced by glycation.
Diabetes  •  2020  |  View Paper
Warfarin , a site IIA drug, progressively displaced both [(64)Cu]Cu-PTSM and [(64)Cu]Cu-ATSM from HSA.
Journal of pharmaceutical sciences  •  2009  |  View Paper
The ability of HSA to form ternery complexes with other neutral molecules such as warfarin , which also binds within the subdomain IIA pocket, increases our understanding of the binding dynamics of exogenous drugs to HSA.
The FEBS journal  •  2006  |  View Paper
The two highest levels of oxidation of HSA (CT10-HSA, CT50-HSA) resulted in conformational changes with an increased exposure of hydrophobic regions, decreased high-affinity bindings of warfarin and ketoprofen and a reduced esterase-like activity.
Pharmaceutical Research  •  2004  |  View Paper
The binding of either dicoumarol or warfarin to HSA quenches the native tryptophan fluorescence of the protein.
The binding of warfarin to HSA is also accompanied by a 7-fold increase in the fluorescent yield of the drug and a shift of its fluorescence emission maximum from 400 mµ to 390 mµ. This suggests that warfarin is bound to a hydrophobic area of the HSA molecule.
Molecular pharmacology  •  1970  |  View Paper
The retention of warfarin on the entrapped HSA was at least 1.7-fold higher than has been obtained under comparable support and mobile phase conditions when using covalent immobilization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2019  |  View Paper
The inhibitory effects of warfarin and indomethacin on the esterase activity of HSA to aspirin were stronger than that of naproxen.
Biological & pharmaceutical bulletin  •  2016  |  View Paper
Furthermore, the binding of MO to HSA was inhibited by warfarin.
Biomedical research  •  2015  |  View Paper
Furthermore, the binding ability of HSA to warfarin and ketoprofen was more effectively decreased by methylglyoxal modification than the other aldehydes.
Journal of pharmaceutical sciences  •  2010  |  View Paper
However, warfarin has strong binding to HSA and the two chiral forms of warfarin have slightly different binding affinities for this protein.
Journal of chromatography. A  •  2009  |  View Paper
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