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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Warfarin
supplement:
Polypeptides
Research Papers that Mention the Interaction
“Specifically, variants in the genes that encode an enzyme responsible for the metabolism of warfarin [cytochrome P450, family 2, subfamily C, polypeptide 9 ( CYP2C9 )3] and the molecular target of warfarin [vitamin K epoxide reductase complex, subunit 1 ( VKORC1 )] influence warfarin dosing.”
Genotype-guided dosing of warfarin.“Genetic variations in the cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9), vitamin K epoxide reductase complex, subunit 1 (VKORC1), and gamma-glutamyl carboxylase (GGCX) genes have been shown to contribute to impaired metabolism of warfarin.”
“BACKGROUND Polymorphisms of the CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) gene (CYP2C9*2, CYP2C9*3) and the VKORC1 (vitamin K epoxide reductase complex, subunit 1) gene (-1639G>A) greatly impact the maintenance dose for the drug warfarin.”
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