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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Warfarin
supplement:
Andrographolide
Research Papers that Mention the Interaction
“Additionally, the metabolic stability of warfarin increased from 23.5 ± 4.7 to 38.7 ± 6.1 min with the pretreatment of andrographolide , and the difference was significant (p < 0.05).”
“However, the herb-drug interaction between andrographolide and warfarin is still unknown.”
“The pharmacokinetic …-administration of andrographolide could … of warfarin significantly, including area under the curve (118.92 ± 18.08 vs. 60.58 ± 9.46 μg × h/mL), maximum plasma concentration (… vs. 2.35 ± 0.25 μg/mL) and t1/2 (22.73 ± 3.28 vs. 14.27 ± 2.67 h).”
Influence of andrographolide on the pharmacokinetics of warfarin in rats
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