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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Voriconazole
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Co-administration of phenytoin or rifampicin, St John's wort or glucocorticoids significantly increased voriconazole elimination.”
Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing.“Clinical trials indicate … wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (and/or increases the clearance) of alprazolam, amitriptyline, …, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine, omeprazole, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol, verapamil, voriconazole ….”
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