Possible Interaction: Vitamin K and Vitamin K-Dependent Protein C

“ Vitamin K is involved in the γ-carboxylation of the vitamin K-dependent proteins , and vitamin K epoxide is a by-product of this reaction.”

“ Vitamin K acts as a cofactor and is required for post-translational γ-carboxylation of vitamin K-dependent proteins (VKDP).”

“This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.”

“Background Vitamin K inhibits prostate cancer cells, and an altered expression of vitamin K-dependent proteins in prostate tumors has been linked to their aggressiveness and progression.”

“Areas covered: We advance the hypothesis that modulation of vitamin K-dependent MGP activation in IPF patients by either vitamin K antagonism or administration may result in acceleration and deceleration of fibrosis progression, respectively.”

“These vitamin K-dependent proteins may exert their functions following γ-carboxylation with vitamin K , and different vitamin K-dependent proteins may exhibit synergistic effects or antagonistic effects on each other.”

“BACKGROUND & AIMS Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins , including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein.”

“ Vitamin K is a cofactor for the post-translational carboxylation of several vitamin K-dependent proteins.”

“The suboptimal availability or impaired utilization of vitamin K impedes the c-carboxylation of vitamin K-dependent (VKD) proteins , leading to the release into the circulation of undercarboxylated VKD proteins that have reduced biological activity (known as PIVKAs, protein-induced vitamin K absence) [3].”

“ Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins.”