Possible Interaction: Vitamin K and Raloxifene

“ Menadione and raloxifene weakly inhibited Bcrp1, but the inhibition of raloxifene on MDR1 was as potent as on the xanthine oxidase pterin oxidation.”

“On the other hand, the results of a … suggest the possible efficacy of combined treatment with vitamin K2 … raloxifene in the prevention of vertebral and hip fractures in postmenopausal women, although no clinical studies … the effects of combined treatment with vitamin K2 and raloxifene in postmenopausal women with osteoporosis.”

“Thus, we propose that the important role of vitamin K2 used in combination with bisphosphonates or raloxifene should not be underestimated in the prevention of fractures in postmenopausal women with osteoporosis with vitamin K deficiency.”

“Therefore, raloxifene and vitamin K2 had complementary effects on bone resorption and formation activities, respectively, resulting in a reproducible, significant improvement of femoral neck strength.”