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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin K
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“… vitamin K is a cofactor for …-translational g-carboxylation of glutamic acid residues on several proteins, including coagulation factors II (prothrombin), VII, IX, and X. Although coumarins also inhibit the g-carboxylation of anticoagulant proteins C, S, and Z, inhibition of clotting factor activity is their main pharmacologic effect.”
The genetics of vitamin K antagonists“This is consistent with our previous observation that binding of a glutamic acid-containing substrate activates vitamin K epoxidation and supports the hypothesis that binding of the carboxylatable substrate to the enzyme results in a conformational change which renders the enzyme catalytically competent.”
“Serum concentration of vitamin K 1 correlated positively with that of 25(OH)D 3 ( r =.423, P <.001) and MMSE score ( r =.353, P <.001), and negatively with Glu OC ( r =-.580, P <.001).”
“When vitamin K was used as the cofactor in the enzymatic reaction, carboxylation of glutamic acid was also found to be reduced in both biliary diverted as well as in biliary intact rats.”
Effect of biliary diversion on the ability of cefamandole to inhibit vitamin K metabolism.
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