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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Several studies … that vitamin K-dependent proteins may also play … role in renal calcium (Ca) handling, and that vitamin D deficiency may lead to excess urinary Ca loss, but the effect of … vitamin K antagonist warfarin on urinary Ca excretion and CaOx growth inhibition in humans is not known.”
The effect of warfarin on urine calcium oxalate crystal growth inhibition and urinary excretion of calcium and nephrocalcin“ Vitamin K-dependent factors form enzymatic complexes with calcium and membrane phospholipids.”
“ Calcium inhibited the activation of human protein C by the venom protease (Ki = 93 microM).”
“The action of this vitamin K-dependent protein would oppose net calcium loss in the tibial metaphysis of 1,25-(OH)2D3-treated rats.”
Concurrent warfarin treatment further reduces bone mineral levels in 1,25-dihydroxyvitamin D3-treated rats.“At higher protein concentrations (5 to 10 mg per ml), a similar phenomenon is observed, but only after several prior additions of Ca++ ; endogenous material (termed Hr) present, in terms of Ca++, at levels of approximately 40 mpmoles per mg of protein counteracts the initial absorbance increase.”
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