Possible Interaction: Vitamin K and Calcium Supplement

“In fast losers of urinary calcium vitamin K induced a 30% decrease of calcium excretion.”

“Data suggest that VitK2 supplementation might improve bone quality and reduce fracture risk in osteoporotic patients, potentially enhancing the efficacy of Ca ± vitD. Mg deficiency could negatively influence bone and muscle health.”

“Background and Objectives: Vitamin K (VK) plays a major role in modifying the binding of calcium in bones and blood vessels.”

“Regarding the parameters of bone metrology and biomechanics, the effect of vitamin K1 combined with calcium on the prevention of osteoporosis is better than that of vitamin K1 or calcium alone, and the treatments with VK and Ca had better effects on femur than lumbar spine.”

“ Vitamin K plays an important role in calcium homeostasis, reduces arterial calcification and arterial stiffness and, as a result, has a protective effect when taking calcium.”

“In the HA group, significantly positive correlations were observed between phylloquinone and Ca (r = 0.495; p = .027), also, indicates negative significant correlation between cholecalciferol and Co (r = −0.598; p = .031).”

“Adding vitamin K1 to vitamin D and calcium reduced the lifetime probability of at least one fracture by 20%, increased discounted survival by 0.4 QALYs (95% CrI −1.9; 1.4) and discounted costs by $4,014, yielding an ICER of $9,557/QALY.”

“In recent years, several authors have included vitamin K as a possible protective factor, interacting with calcium and vitamin D in the maintenance of both bone and cardiovascular health [2].”

“In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.”

“The role of vitamin K in bone health is less well defined, though it may enhance the actions of Ca and vitamin D. Sr administered in pharmacological doses as the ranelate salt was shown to prevent fragility fractures in postmenopausal osteoporosis.”