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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Vitamin E and Warfarin

supplement:

Vitamin E

Research Papers that Mention the Interaction

To clarify whether vitamin E enhances the pharmacologic effect of warfarin , we completed a double-blind clinical trial in which 21 subjects taking chronic warfarin therapy were randomized to receive either vitamin E or placebo.
The American journal of cardiology  •  1996  |  View Paper
However, when made mildly vitamin-K-deficient by using warfarin , the introduction of vitamin E produced a profound coagulopathy.
The American journal of pediatric hematology/oncology  •  1979  |  View Paper
An example of the latter would be in patients who are vitamin K deficient, perhaps through anticoagulation with drugs such as warfarin , in which case use of high doses of α-tocopherol may increase the bleeding tendency.
Drug safety  •  1995  |  View Paper