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“To clarify whether vitamin E enhances the pharmacologic effect of warfarin , we completed a double-blind clinical trial in which 21 subjects taking chronic warfarin therapy were randomized to receive either vitamin E or placebo.”
The American journal of pediatric hematology/oncology • 1979 | View Paper
“An example of the latter would be in patients who are vitamin K deficient, perhaps through anticoagulation with drugs such as warfarin , in which case use of high doses of α-tocopherol may increase the bleeding tendency.”