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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The mechanisms by which vitamin E interferes with vitamin K activity , especially blood clotting, are not known, but hypothetically this interference may involve metabolic pathways.”
Vitamin E and K interactions--a 50-year-old problem.“We speculate that a potential mechanism may involve vitamin E interference in vitamin K activation.”
“BACKGROUND Supplementation with vitamin E may antagonize vitamin K in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE).”
“ Vitamin E and its inhibitory effects on vitamin K synthesis may have been a source of the elevated INR and PT, but INR and PT were stable before the initiation of celecoxib.”
“We have reported that vitamin E intake lowers phylloquinone (PK) concentration in extrahepatic tissues of rats.”
Tissue Distribution of Menaquinone-7 and the Effect of α-Tocopherol Intake on Menaquinone-7 Concentration in Rats.“Furthermore, α-T may interfere with the side chain removal of phylloquinone (PK) to form menadione (MN) as an intermediate for synthesis of tissue-specific menaquinone-4 (MK-4).”
“Retinol acetate, tocopherol acetate , and phylloquinone administered in various pair combinations reduce the degree of changes in the parameters of nonspecific resistance and immunological reactivity.”
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