Possible Interaction: Vitamin E and Tocotrienols

“ α-Tocopherol attenuates the cholesterol-suppressive action of the tocotrienols.”

“In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol.”

“Furthermore, coadministration of α-Toc decreased liver and adipose tissue concentrations of tocotrienols in F344 rats.”

“Yet, of all papers on vitamin E listed in PubMed less than 1% relate to tocotrienols.”

“Thus, the transport, tissue concentration, and relative biologic function of tocopherol and tocotrienol appear somewhat disparate and possibly unrelated.”

“Here, we investigated the inhibitory effect of vitamin E , with particular emphasis on tocotrienol (unsaturated vitamin E), on human telomerase in cell-culture study.”

“Although tocotrienols were similarly detected in TRPs, LDLs, and HDLs, tocotrienol concentrations were significantly lower than alpha-tocopherol concentrations.”

“The protective effect of tocomin was replicated when the tocotrienols were present with, but not without, α-tocopherol.”

“Moreover, other lipophilic antioxidants, such as tocotrienols , tert-butylhydroquinone, and butylated hydroxyanisole, also inhibited T0070907-induced apoptosis like α-tocopherol.”

“In contrast to … intake, α-tocopherol , which has the highest affinity for … transfer protein (αTTP), inhibited uptake of γ-tocotrienol to tissues including adipose tissue after oral administration, suggesting that the affinities of tocopherol and … αTTP in the liver were the critical determinants of their uptake to peripheral tissues.”