Possible Interaction: Vitamin E and Tocopherylquinone

“After subjects consumed fish oil, supplementation with alpha-tocopheryl acetate increased plasma and LDL alpha-tocopherol contents significantly and lengthened lag time (at even the lowest concentration) but had no significant effect on propagation rate or maximum production compared with values measured after consumption of fish oil alone.”

“ alpha TTA was inhibited only 5% in the presence of a 32-fold excess of cold liposomal alpha-tocopheryl acetate suggesting that the free hydroxyl group on the chromanol ring of alpha-tocopherol is needed for transfer.”

“The formation of alpha-tocopherolquinone appeared inversely related to the decrease of alpha-tocopherol.”

“We have also found that the level of alpha-tocopherolquinone , an oxidation product of alpha-tocopherol, increases as the alpha-tocopherol is consumed.”

“These data show that TQ arising from excessive oxidative degradation of Toc can potentially interfere with mitochondrial electron transfer.”

“In addition, supplementation with alpha-tocopheryl acetate increased the alpha-tocopherol content, whereas 2-thiobarbituric acid (TBA) values and lipid hydroperoxide content were reduced.”

“Supplementation with alpha-tocopheryl acetate increased alpha-tocopherol concentrations approximately 3-5-fold in plasma and in tissue homogenates and approximately 2-3-fold in mitochondria from liver, skeletal muscle and heart of the mice.”

“This research examined the effects of dietary alpha-tocopheryl acetate (50 or 200 mg/kg … and stored for 24 h at 5 degrees C. The higher amount of dietary alpha-tocopheryl acetate … Vitamin E in the fresh semen (1.75 mmol/l … 21.4 nmol malondialdehyde/10(8) sperm).”

“CONCLUSIONS AND CLINICAL RELEVANCE Supplementation with al ha-tocopheryl acetate in creased ser um alpha-tocopherol co ncentrations and eliminated the decrease in alpha-tocopherol concentration that was detected after a race, which may decrease oxidation during exercise and improve performance or recovery.”

“The alpha-tocopherol content in muscle from pigs fed diets supplemented with alpha-tocopheryl acetate (100 mg/kg feed) was 1.5 times greater (p < 0.0001) than those from pigs receiving a basel diet.”