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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin E
supplement:
Tocophersolan
Research Papers that Mention the Interaction
“Following bile duct … rat, TPGS promoted … alpha-tocopherol while absorption of gamma-tocopherol from soybean oil was decreased 30 fold, demonstrating that TPGS, which forms a micellar solution, delivers … through the unstirred water layer to enterocytes, while free tocopherol (alpha or gamma) absorption requires the presence of bile salts.”
Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats.“Administration of 400 IU (269 mg), 800 IU (537 mg), and 1200 IU (807 mg) TPGS as a single dose resulted in slight elevation of plasma alpha-tocopherol concentrations.”
“Administration of multiple daily doses at all three amounts of TPGS for 28 consecutive days resulted in a slight elevation of plasma alpha-to-copherol concentrations.”
“Combinations of Pluronic F127 or Pluronic F108 with Vitamin E TPGS showed significantly stronger inhibition than the individual surfactants, indicating synergistic effects on inhibition of drug precipitation.”
Combination of Pluronic/Vitamin E TPGS as a potential inhibitor of drug precipitation.“Therefore, modulator effect of AT and GT were greater than that of TPGS.”
“In addition, the presence of 3% Vitamin E TPGS lowered the T(g) over 11 degrees C when compared with the HPC/PEO 50:50 blend film without TPGS, thus functioning as a plasticizer.”
“The addition of 1, 3, and 5% Vitamin E TPGS , respectively, decreased the glass transition temperature of the extruded films containing either a 50:50 or 80:20 ratio of HPC to PEO in an almost linear fashion.”
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