Possible Interaction: Vitamin E and Ritonavir

“Since inflammation is a major player in the pathogenesis of atherosclerosis, we hypothesized that HPI drugs, such as ritonavir , increase proinflammatory cytokines synthesis and that alpha-T supplementation counteracts this effect by suppressing proinflammatory cytokines levels.”

“Both compounds produced comparable amounts of oxidative stress; however, normalization by α‐tocopherol occurred solely after inhibition by ritonavir , and not by ALLN.”

“Since oxidative stress was reduced by α‐tocopherol only after proteasome inhibition by ritonavir and not by ALLN, it is concluded that, in this experimental system, α‐tocopherol does not act as an antioxidant but interferes with the inhibitory effect of ritonavir.”

“Furthermore, in THP-1 monocytes, alpha-tocopherol reverses the proteasome activity inhibited by ritonavir.”