Possible Interaction: Vitamin E and Linolenic Acid

“ResultsDietary intake data showed that as vitamin E intake increased, intakes of total polyunsaturated fatty acid (PUFA) and α-linolenic acid increased significantly (p < 0.001), but eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) did not.”

“In the presence of anti-oxidants vitamin E), ALA and GLA dramatically lost their ability to inhibit FAS activity.”

“Feeding n-3 FA and α-tocopherol increased plasma concentrations of the n-3 FA, including α-linolenic , eicosapentaenoic, and docosahexaenoic acids, with a concomitant decrease in oxidant status index during the first week of life.”

“Superoxide dismutase (SOD) completely blocked, while vitamin E and reduced glutathione (GSH) could prevent to a limited extent the anti-proliferative effects of ALA and EPA.”

“Both SOD and vitamin E could inhibit the action of ALA and EPA indicating a role for reactive oxygen species and lipid peroxides.”

“Cosidering linolenic and arachidonic acids, prooxidant effect increased with alpha-tocopherol level while for linoleic acid this effect was similar with all alpha-tocopherol concentrations.”

“Linoleic, linolenic and arachidonic acids, dispersed at a concentration of 2.5 x 10-3 M in an aqueous media pH 7.3, exhibited increasing of their autoxidation rate in presence of 1.5 x 10-5M alpha-tocopherol or more.”