Possible Interaction: Vitamin E and Leptin

“Moreover a negative and significative correlation between vitamin E and leptin (r = 0.452 ; p = 0.01), and a negative and no significative correlation between vitamin A and leptin (2 = - 0.221; p > 0.05) were observed.”

“The vitamin E could have a negative control on the secretion of the leptin.”

“Cows supplemented with combination of Zn and VE showed minimum decline in plasma concentration of leptin , insulin, GH, IGF-1, T3, and T4, and minimum increase in cortisol concentration.”

“Administration of PVE also significantly reduced leptin level in the HCHF rats.”

“In … experiment vitamin E addition … in leptin plasma levels (Fisher's test, 3L versus 3LE: p≤0.002) and an increase in leptin expression in all three aortic … test, 3L versus 3LE p≤0.005, p≤0.01 and p≤0.05 respectively for endothelium, tunica media and adventitia).”

“It may suggest that vitamin E consumption plays an important role in the control of leptin status in the endothelium.”

“The study showed that vitamin E supplementation influenced leptin expression in aortic layers in rats fed atherogenic diet differently depending on the length of feeding period.”

“Administration of VE decreases leptin and adiponectin expression in obese rats.”

“ VE intervention increased the expression of both leptin and adiponectin (P values < 0.05).”

“The results indicated that VitA and VitE significantly reduced the levels of leptin , TNF-α, IL-6 and CRP and the ESR and significantly increased the levels of IL-10 compared with those of the model group.”