Possible Interaction: Vitamin E and Iron, Dietary

“The addition of iron to all three diets resulted in significantly lower serum vitamin E levels at 6 weeks (P less than 0.05); however, only in the group fed formula was there evidence of vitamin E deficiency.”

“ Vitamin E and melatonin can prevent the majority of metal-mediated ( iron , copper, cadmium) damage both in vitro systems and in metal-loaded animals.”

“For colonocytes, high dietary Fe decreased tocopherol levels.”

“Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the same two proteins that can be blocked by α‐tocopherol and desferrioxamine.”

“We studied the effects of a single oral dose of vitamin E taken 6 h prior to intravenous infusion of 100 mg iron , which exceeded the iron-binding capacity of transferrin.”

“Hydroxyl radical scavengers such as vitamin E , dimethyl-sulfoxide (DMSO) and mannitol reduced endogenous ROS generation and alleviated the cytotoxic effects of iron.”

“Zinc and vitamin E intakes were well below recommended levels throughout the study, and iron decreased markedly from 96% of the recommended level at 12 months old to 76% at 18 months old.”

“Intracellular chelation of … preloading cells with iron enhanced, toxicity, Inhibition of oxidized LDL and 7 beta-OOH chol toxicity …-4-thiolmethyl butyric acid, a putative alkoxyl radical scavenger and by vitamin E , probucol and diphenylphenylenediamine, putative scavengers of peroxyl radicals was … involvement of these radicals in the lethal sequence.”

“ Fe enhanced the formation of both the CD and TPPO and increased the percentage of dead cells, while vitamin E inhibited these effects.”

“The possible importance of alpha-tocopherol in preventing the toxic effect of iron on the apparently very sensitive myocardium after parenteral iron to patients with severe malabsorption syndrome is discussed.”