Possible Interaction: Vitamin E and Interleukin-10

“Both resveratrol (5 …(-1)) and vitamin E (80 mg kg(-1) … reduced AST, ALT, GST, IL-10 , TNF-alpha, IFN-gamma, VEGF-A and TGF-beta1 activities and levels of TBARS and nitrite, … content, GSH level and activities of SOD, CAT, GR and GPx, compared to ethanol-treated group.”

“In conclusion, our results revealed that vitamin E is able to suppress IL-10 production and to influence the production of IL-2, IL-4, and maybe TBX21.”

“Regarding cytokine production, vitamin E consistently decreases the mRNA expression and the percentage of cells producing IL-10.”

“ Tocopheryl acetate treatment significantly reduced AST (62.83%); ALT (61.54%); IL-10 (36.35%): IFN-gamma (23.28%) activities and TBARS content (35.84%).”

“Furthermore, the vitamin E depletion increased the cellular content and secretion of IL10 in type II cells, but decreased the content and secretion of TNFalpha.”

“Adding 500 IU of vit-E to the FO diet further lowered the levels of IL-6, IL-10 , IL-12, and TNF-alpha.”

“The FO diet containing 500 IU of vit-E may specifically modulate the levels of IL-6, IL-10 , IL-12 and TNF-alpha and thereby may delay the onset of autoimmunity in the MRL/lpr mouse model.”

“ IL-10 concentration increased in DCs treated with MSC ( Vit E ) and MSC (Se) CM.”

“The results indicated that VitA and VitE significantly reduced the levels of leptin, TNF-α, IL-6 and CRP and the ESR and significantly increased the levels of IL-10 compared with those of the model group.”