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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin E
supplement:
Gamma-Linolenic Acid
Research Papers that Mention the Interaction
“In contrast, anti-oxidants such as vitamin E blocked the tumoricidal action of GLA.”
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies.“GLA treatment could also elevate lipid peroxidation in K562 cells, and antioxidant α‐tocopherol could reverse the cytotoxicity of GLA.”
“In the presence of anti-oxidants vitamin E ), ALA and GLA dramatically lost their ability to inhibit FAS activity.”
“ GLA , EPA, and DHA-induced free radical generation and lipid peroxidation were also inhibited by vitamin E and SOD.”
“On the other hand, the anti-oxidant, vitamin E , and the superoxide anion quencher, superoxide dismutase (SOD), could completely inhibit the cytotoxic action of GLA , EPA and DHA indicating a role for free radicals and, in particular, the superoxide anion in this process.”
“Addition of vitamin E decreased the effects of GLA and EPA, which supports the hypothesis of direct action by these fatty acids.”
“On the other hand, 4 antioxidants (Coenzyme Q, (D) alpha-tocopherol , (DL) alpha-tocopherol, butylated hydroxytoluene) reduced the growth inhibitory effect of GLA , but not in proportion to the decrease of GLA-stimulated lipid peroxidation.”
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