Possible Interaction: Vitamin E and Folate

“It has been suggested that folate deficiency may aggravate haemolysis in vitamin E deficiency,2' but though the patient's folate status was not certain his marrow was normoblastic, a finding which suggested that he did not have severe folate deficiency.”

“Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels.”

“In women, the odds of meeting the folate and vitamin E EAR were lower in the Y/Y group.”

“The fortification of food with vitamin E and folate raised the low intakes from non-fortified food (about 50% of reference intake values) to about 80% (folate) and 100% (vitamin E) of the references.”

“Although Vit E or folate had some protective effect, combination therapy with Vit E and folate attenuated all the changes due to H2O2 toxicity.”

“The present findings indicate that co-administration of Vit E and folate before and during pregnancy may maintain a viable pregnancy and contribute to its clinical efficacy for the treatment of some idiopathic infertility.”

“However, combined deprivation of folate and vitamin E resulted in levels of glutathione intermediate between those observed following deprivation of either agent, indicating that the lack of compensatory increase in glutathione following vitamin E deprivation was not due to overt neurotoxicity.”

“The differential response to vitamin E and folate deprivation is consistent with the possibility that specific differences in oxidative damage may result from deficiencies in either of these agents.”