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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin E
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“Furthermore, vitamin E abolished both DHA effects on chemotherapy efficacy enhancement and on GPx1 inhibition.”
Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response.“This cytotoxic effect of DHA was reversed by pretreatment with vitamin E , suggesting that the enhanced toxicity of GPx-4 knockdown is due to changes in the ability of the cells to handle oxidative stress.”
“Lipid peroxidation has been cited by others as an important component of DHA toxicity, and we confirmed that vitamin E prevents the cytotoxic effects of DHA.”
“The DHA-effect on [Ca2+]i was time dependent and occurred at 48 h, … DHA-content in phospholipids reached a plateau already at 24 h. The antioxidant vitamin E , the lipoxygenase inhibitor NDGA and the cytochrome … inhibitor SKF 525A completely prevented the DHA induced reduction of … [Ca2+]i-increase.”
Docosahexaenoic acid inhibits PAF and LTD4 stimulated [Ca2+]i-increase in differentiated monocytic U937 cells.“This study demonstrated that incorporation of α-tocopherol into liposomes contributes a significant antioxidant effect on DHA and EPA.”
Physicochemical properties and antioxidant activity of α-tocopherol loaded nanoliposome's containing DHA and EPA.
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