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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Vitamin E
drug:
Crizotinib
Research Papers that Mention the Interaction
“Although α-tocopherol suppressed the inhibitory effects of crizotinib on the signaling axis including NPM-ALK and STAT3, it had no influence on the intake of crizotinib into cells.”
“The administration of α-tocopherol attenuated the anti-tumor activity of crizotinib against NPM-ALK-provoked tumorigenesis in vivo.”
“We found that α-tocopherol , a major component of vitamin E, attenuated the effects of crizotinib independently of its anti-oxidant properties.”
“Whereas the nuclear localization of NPM-ALK was disappeared by the treatment with crizotinib, the co-treatment with α-tocopherol swept the effect of crizotinib and caused the localization of NPM-ALK in nucleus.”
Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK
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