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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Vitamin E and Celecoxib

supplement:

Vitamin E

Research Papers that Mention the Interaction

This vitamin E TPGS-based microemulsion significantly increased the in vitro intestinal absorption of celecoxib compared to celecoxib solution.
International journal of nanomedicine  •  2019  |  View Paper
However the co-administration of vitamin E with celecoxib caused a significant increase in the antinociceptive effect which was similar to indomethacin, as a standard anti-inflammatory drug.
However, in tail-flick … ineffective doses of vitamin E (200 … celecoxib (10 and 30 mg/kg) increased %MPE and AUC compared to vehicle but not compared to celecoxib or vitamin … E and celecoxib showed a dose related antinociceptive effect in inflammatory but not in thermal model of acute pain.
The combination of vitamin E (100 or 200 mg/kg) with celecoxib (3 or 10 mg/kg) decreased pain scores compared to vehicle in both phases of formalin test, while in chronic phase (II) the pain scores of combination groups were also decreased compared to vitamin E and celecoxib.
Pharmacological reports : PR  •  2019  |  View Paper