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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Vitamin E and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

After treatment with vitamin E, ADMA decreased by 23% in six of eight patients (P <0.001).
We hypothesized that the antioxidant alpha-tocopherol (vitamin E) reduces ADMA levels in CKD.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2003  |  View Paper
Angiotensin-converting enzyme inhibitors, angiotensin AT1 receptor antagonists, vitamin E and, according to some studies, estrogens used in hormonal replacement therapy reduce plasma ADMA concentration, which may contribute to their beneficial effect on NO synthesis and endothelial function.
Pharmacological reports : PR  •  2006  |  View Paper
Analysis of separate treatment effects suggested that vitamin E significantly decreased ADMA levels by 4% in the treatment group compared with the placebo group (multiple adjusted P = 0.02).
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  2009  |  View Paper
Moreover, vitamin E decreased ADMA contents by up-regulating dimethylarginine dimethylaminohydrolase (DDAH) activity in adipocytes.
Vitamin E reduced the effects of ADMA on glucose transport system, and on NO, ROS and TLR4.
Cellular Physiology and Biochemistry  •  2009  |  View Paper