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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin E
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“After treatment with vitamin E, ADMA decreased by 23% in six of eight patients (P <0.001).”
“We hypothesized that the antioxidant alpha-tocopherol (vitamin E) reduces ADMA levels in CKD.”
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.“Angiotensin-converting enzyme inhibitors, angiotensin AT1 receptor antagonists, vitamin E and, according to some studies, estrogens used in hormonal replacement therapy reduce plasma ADMA concentration, which may contribute to their beneficial effect on NO synthesis and endothelial function.”
“Analysis of separate treatment effects suggested that vitamin E significantly decreased ADMA levels by 4% in the treatment group compared with the placebo group (multiple adjusted P = 0.02).”
“Moreover, vitamin E decreased ADMA contents by up-regulating dimethylarginine dimethylaminohydrolase (DDAH) activity in adipocytes.”
“ Vitamin E reduced the effects of ADMA on glucose transport system, and on NO, ROS and TLR4.”
Asymmetric Dimethylarginine Impairs Glucose Utilization via ROS/TLR4 Pathway in Adipocytes: an Effect Prevented by Vitamin E
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