Possible Interaction: Vitamin E and Ascorbate

“However, this pro-oxidant activity of alpha-tocopherol is prevented by ascorbate acting as a coantioxidant.”

“An accumulation of native lipoproteins which present a decreased alpha-tocopherol on triglycerid ratio and a modification in the plasmatic balance between alpha-tocopherol and ascorbate could explain these observations.”

“Numerous in vitro experiments demonstrate antioxidant synergism between alpha-tocopherol and ascorbate , reduced glutathione, NADPH, and cellular electron transport proteins.”

“ Vitamin E and its combination with zeaxanthin can enhance protective effects of ascorbate , but do not ameliorate its deleterious effects.”

“ α‐Tocopherol and its combination with zeaxanthin enhanced protective effects of ascorbate , but did not prevent from ascorbate‐mediated deleterious effects.”

“Both alpha-tocopherol and ascorbate treatment over a time course of 72 hours caused a significant reduction in apoA-I messenger RNA and protein levels in a dose-dependent fashion.”

“Preincubation of platelets with ascorbate blocked the oxidation of tocopherol.”

“The effects of alpha-tocopherol on citrulline and cGMP formation and eNOS phosphorylation were amplified by co-incubation with ascorbate , which is suggested to regenerate oxidized alpha-tocopherol and to act synergistically with alpha-tocopherol.”

“The inhibitory effect of α-tocopherol increased rapidly with the increasing ascorbate concentration, almost complete inhibition of NADPH-dependent lipid peroxidation being obtained at 25 μM α-tocopherol and 50 μM ascorbate.”

“This strong inhibitory combined effect of α-tocopherol and ascorbate was independent of the Fe3+/Fe2+ ratio, as a-tocopherol is not able to reduce Fe3+ to Fe2+ under the conditions employed.”

“ Ascorbate could contribute to reduction of the increased oxygen free radicals generated in sickle red blood cells (SRBC) and to the recycling of vitamin E in the cells, while renal loss could contribute to the low plasma levels.”

“When erythrocytes were loaded with ascorbate , DABS-dependent loss of alpha-tocopherol was decreased, despite little change in intracellular ascorbate content.”