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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Vitamin E
supplement:
Alpha-Tocopherol Succinate
Research Papers that Mention the Interaction
“ alpha-TOS inhibited proliferation of the cells and induced their apoptosis in a concentration- and time-dependent manner, while succinate or alpha-tocopherol showed no effect.”
alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner.“While alpha-tocopherol , tocopherol acetate and tocopherol phosphate moderately reduced the dye transfer, TS at 10 and 25 microM strongly inhibited it, probably via the induction of the hypophosphorylation of connexin 43.”
The vitamin E analog tocopherol succinate strongly inhibits gap junctional intercellular communication in rat liver epithelial cells (IAR203).“Cellular pretreatment with non‐toxic levels of 25 μMα‐tocopherol succinate (vitamin E) for 24 h prior to exposure resulted in a 10‐fold increase in cellular levels of α‐tocopherol.”
“Supplementation of the calcium-depleted hepatocytes with alpha-tocopheryl succinate (25 microM) markedly elevated their alpha-tocopherol content and prevented the toxicities of both drugs.”
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