Possible Interaction: Vitamin E and Aldesleukin

“ Vitamin E also enhances IL-2 production, expression of several cell cycle control proteins, and proliferation.”

“Compared with the basal diet, the diet supplemented with 480 mg kg(-1) vitamin E significantly augmented the mRNA expression of IL-1β , TNF-α in the spleen and head-kidney, C3 in the liver, respectively.”

“The result suggests that vitamin E may have a controlling effect on oxidative stress through modulation of SOD and IL-2 expression.”

“In conclusion, our results revealed that vitamin E is able to suppress IL-10 production and to influence the production of IL-2 , IL-4, and maybe TBX21.”

“ Vitamin E supplementation, in aged animals and humans, increases cell division and IL-2 production by naive T cells.”

“ Vitamin E supplementation resulted in higher up-regulation of IL-2 expression in young and old T cells and lower up-regulation of IL-4 expression in old T cells following stimulation.”

“Low-dose (50 microM) alphaTOC increased IL-2 expression, which may have been due to the absence of downregulation of PPARgamma and IkappaBalpha on the IL-2 gene.”

“ Vitamin E had marked inhibitory effects on the ability of cells treated with IL-2 or TNF-alpha to reproduce or synthesize collagen.”

“Dietary supplementation, with a 15-, 150- and 450-fold increase of vitamin E in a liquid diet, significantly restored levels of interleukin-2 (IL) and interferon-gamma produced by splenocytes, which were suppressed by retrovirus infection.”

“Dietary supplementation, with a 15-, 150- and 450-fold increase of vitamin E in the diet modulated interleukin-2 (IL) production in both uninfected mice and retrovirus-infected mice.”