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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“More rapid artery calcification was induced by treatment with warfarin together with high doses of vitamin D , a procedure that causes extensive artery calcification by 84 hours.”
Bisphosphonates Alendronate and Ibandronate Inhibit Artery Calcification at Doses Comparable to Those That Inhibit Bone Resorption“Resistance to warfarin in R. norvegicus may be correlated with susceptibility to calciferol, and further studies on mixtures of calciferol and warfarin showed that there was an additive effect between the components.”
“The CC type VKORC1 genetic polymorphism was associated with a significantly higher mean warfarin maintenance dose (4.5 ± 0.5 mg) than other VKORC1 genotypes (TT type 2.9 ± 0.1 mg: CT type 3.4 ± 0.3 mg).”
“ Warfarin inhibited the promotive effects of vitamin K2 in the presence of vitamin D3.”
“Because Warfarin treatment had no effect on the elevation in serum calcium produced by vitamin D, the synergy between Warfarin and vitamin D is probably best explained by the hypothesis that Warfarin inhibits the activity of matrix Gla protein as a calcification inhibitor.”
“High levels of matrix Gla protein are found at sites of artery calcification in rats treated with vitamin D plus Warfarin , and chemical analysis showed that the protein that accumulated was indeed not gamma-carboxylated.”
Warfarin-induced artery calcification is accelerated by growth and vitamin D.“Toxicity tests with calciferol combined with warfarin indicated an additive effect between the compounds.”
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