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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin D
drug:
Tacrolimus
Research Papers that Mention the Interaction
“Moreover, the ratio of tacrolimus C0 over the percent of IL-2–producing CD8+ T cells in CC genotype patients was significantly higher compared with TT genotype patients (P < 0.05), showing a smaller pharmacodynamic effect in CC genotype patients.”
Genetic Polymorphisms in ABCB1 Influence the Pharmacodynamics of Tacrolimus“At 6 and 12 months after transplantation patients who were homozygous for the ABCB1 3435 CC showed significantly lower dose-adjusted trough TRL concentrations compared with subjects of 3435 TT and CT genotypes.”
“Although the effects of Tac on Th17 is limited, combined use of vitamin D and Tac can show a synergistic impact on the suppression of the mTOR pathway and Th17 pathway as shown in our study, as well as in another study on autoimmune disease.”
“The CC patients displayed a lower tacrolimus level per dose than CT/TT patients.”
Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms.
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