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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin D
drug:
Rosuvastatin
Research Papers that Mention the Interaction
“Compared to placebo treatment, rosuvastatin increased 25(OH)D levels (21.6 ± 4.0 vs. 24.1 ± 8.1 ng/ml, p = 0.039).”
25-Hydroxyvitamin D insufficiency is associated with impaired renal endothelial function and both are improved with rosuvastatin treatment“The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine; rosuvastatin ; prednisone and possibly some chemotherapy drugs.”
Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review“Therefore, our initial hypothesis that rosuvastatin may be increasing vitamin D levels by interfering with the metabolism of vitamin D, may be an inadequate explanation.”
“Furthermore it is surprising that blood levels as high … 100 ng/mL was achieved in subjects receiving rosuvastatin especially when the baseline levels were 11.8 ng/mL. As noted by Glossman and Blumenthaler4 this would require ingesting 9,000 IU vitamin D daily for at least 6 weeks.”
“Failure to do this … a study that found rosuvastatin at doses at the level used in … a large and significant impact on vitamin D levels as measured by the metabolite 25-hydroxyvitamin D. The statin alone appears … participants on av-erage went from deficient to sufficient in two months.”
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