Possible Interaction: Vitamin D and Raloxifene

“We found that one week or 2 weeks pretreatment of prepubertal rats with vitamin D analogs led to increased induction of CK by E(2) and by the SERMS tamoxifen, tamoxifen methiodide and raloxifene , in epiphysis and diaphysis of the femur but not in the uterus.”

“We compared changes from baseline in QOL and pain in patients receiving raloxifene plus active vitamin D3 with those in patients receiving raloxifene monotherapy at 8 and 24 weeks after treatment.”

“ConclusionThe study results indicated that raloxifene can transiently reduce the levels of bone metabolism markers … be useful for preventing fractures in postmenopausal women with end-stage renal failure, although raloxifene use over the long term may not have … efficacy in the absence of appropriate concomitant active vitamin D therapy.”

“Combination therapy of raloxifene with other agents including vitamin D has been reported and its effect on fracture prevention remains to be elucidated.”

“However, it still remains unclear from this study whether the combination therapy of RLX and ALF is more efficacious in preventing fractures compared with RLX alone.”

“Conclusion: The combination treatment of RLX and vitamin D prevented a decrease in local BMD (greater tuberosity of the proximal humerus) and enhanced tendon-to-bone healing of the rotator cuff in a rat model.”

“In intact female rats, all Vitamin D analogs also potentiated the in vivo CK response to the SERMs raloxifene (Ral) and tamoxifen (TAM) in Ao and Lv.”