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Last Updated: 3 years ago

Possible Interaction: Vitamin D and Phenylbutyrate

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supplement:

Vitamin D

drug:

Phenylbutyrate

Research Papers that Mention the Interaction

“ PBA co-treatment with 25(OH)D3 synergistically modulated expression of numerous vitamin D-response genes, including CAMP, CYP24A1, CXCL10 and IL-37.”

“This suggests that PBA augments vitamin D –mediated cathelicidin-dependent Mtb growth restriction by human macrophages and independently induces antimicrobial and anti-inflammatory action.”

“We also tested the ability of PBA to enhance the immunomodulatory actions of the vitamin D metabolite 25(OH)D3 during infection and synergistically inhibit intracellular Mtb growth.”

Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃

PLoS pathogens • 2015 | View Paper

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