Possible Interaction: Vitamin D and Multivitamin Preparation

“ Multivitamin intakes during pregnancy were significantly associated with higher serum 25(OH)D levels in the second trimester (β = 9.16, p = 0.005) and the third trimester (β = 13.65, p = 0.003).”

“The spontaneous use of vitamin D supplements and multivitamins was discouraged, but the prescription practices of the general practitioners were not altered.”

“Statistically significant interaction effects were observed between multivitamin use and vitamin B6 intake on myocardial infarction, between multivitamin use and vitamin D intake on CVD mortality, and between multivitamin use and vitamin B12 intake on CVD mortality and total mortality.”

“Inappropriately low UL values, or guidance values, for vitamin D have hindered objective clinical research on vitamin D nutrition, they have hindered our understanding of its role in disease prevention, and restricted the amount of vitamin D in multivitamins and foods to doses too low to benefit public health.”

“A hypothesis now under scientific consideration is that taking vitamin supplements to raise serum 25-hydroxyvitamin D [25(OH)D] concentrations could quickly reduce the risk and/or severity of COVID-19.”

“Conclusion Vitamin D enhances IFN-β induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-β alone.”

“Patients with multivitamin usage had a lower rate of iron deficiency (26% vs. 56%, p = 0.034), vitamin B12 (11% vs. 25%, p = 0.46) and vitamin D (46% vs. 75%, p = 0.07), compared to non-compliant patients.”

“Infants who are given formula and multivitamins for vitamin D supplementation are at increased risk for the formation of urinary tract stones.”

“The use of multivitamins decreased from 37% to 31%, whereas vitamin D significantly increased from 5% to 19%, as did the use of fish oil supplements.”

“The 25(OH)D level in pregnant women compliant with pre-natal calcium or multivitamin supplements was higher than in those not taking supplements (p<0.001).”