Possible Interaction: Vitamin D and Lamotrigine

“These findings indicate that, vitamin D has anti-epileptic, cognitive improving and antioxidant effects, on its own and enhance the effects of lamotrigine , in a chronic model of epileptic seizures.”

“ Cholecalciferol , administered at the subthreshold dose of 18.75μg, potentiated the anticonvulsant activity of oxcarbazepine and lamotrigine , but did not change their brain concentrations, therefore the revealed interactions seem to be pharmacodynamic.”