Possible Interaction: Vitamin D and Interleukin-10

“Proliferation of both freshly isolated CD4+ T cells and MBP-specific T cells was significantly inhibited by 1,25(OH)(2) Vitamin D. Moreover, activated Vitamin D enhanced the development of IL-10 producing cells, and reduced the number of IL-6 and IL-17 secreting cells.”

“Genotype of the latter correlated with the ability of 1,25-(OH)2 D3 and ATRA to inhibit IL-10 production.”

“ Vitamin D also increases synthesis of interleukin 10 by CD4+CD25+Foxp3+ T-regulatory cells and dendritic cells, while concurrently inhibiting dendritic cell activation by downregulating expression of costimulatory molecules CD40 and CD80/86.”

“Existing therapies including corticosteroids and allergen immunotherapy act on Tregs, in part to increase IL‐10 production, while vitamin D3 and long‐acting β‐agonists enhance IL‐10 Treg function.”

“This activity of Vitamin D3 is carried out by inhibiting the production of the proinflammatory cytokines such as tumor necrosis factora (TNF-a) and interferon-g (IFN-g) but, also, by increasing the expression of the anti-inflammatory cytokine interleukin-10 ( IL-10).”

“Levels of 25-hydroxyvitamin D and IL-10 showed a significant rise in both placebo and vitamin D groups following the intervention.”

“Secondary analyses suggest that the effect of Vitamin D on post-MVC pain outcomes may be influenced by genetic variation in IL-10 and NLRP3.”

“Moderate direct correlations were observed between vitamin D and IL-8, IL-10 , and IFN-γ in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-γ r = 0.6, p = 0.015).”

“The GG genotype of the −1082A>G (rs1800896) polymorphism and the CC genotype of the −592C>A (rs1800872) polymorphism were significantly correlated with higher serum IL-10 levels.”

“ Alphacalcidol did not decrease IL-6 (p=0.4) and g- IFN (p=0.001), but it increased IL-10 (p=0,005) and decreased IL6/IL10 ratio (p=0.008).”