Possible Interaction: Vitamin D and Follicle Stimulating Hormone

“ResultsThe median 25(OH)D level was 12 ng/mL, with approximately 75% of participants below the recommended level of 20 ng/mL. FSH and 25(OH)D were inversely related.”

“The correlation with LH/FSH suggests that vitamin D status may contribute to hormonal dysregulation.”

“At completion of CC administration, the median FSH level in 44 cancelled cycles was elevated compared to a control group of 65 completed cycles, 29 IU/l versus 15 IU/l, P less than 0.01.”

“Based on this study, an elevated FSH value following CC administration predicts a poor response to further stimulation with an accuracy of 92.3% and should result in cancellation of the cycle.”

“ D3 did not stimulate lactate production when added alone, but significantly augmented the stimulatory action of FSH on lactate production by Sertoli cells from both LD- and SD-exposed hamsters.”

“We conclude that D3 , probably after hydroxylation to 1,25(OH)2 vitamin D3, modulates the action of FSH on testicular growth and Sertoli cell function.”

“ FSH dose … in CC homozygotes compared with CT heterogeneous (three studies, 949 participants, MD − 75.78, 95%CI − 135.23 to − 16.33, P = 0.01; I2 = … CT/TT model (three studies, 1097 participants, MD − 80.18, 95%CI − 135.54 to − 24.81, P = 0.005; I2 = 42%).”