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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Vitamin D
supplement:
Eldecalcitol
Research Papers that Mention the Interaction
“ Eldecalcitol also decreased the incidence of major osteoporotic fractures in the FRAX more than alfacalcidol (11.1 % vs. 16.3 %; hazard ratio, 0.66; 95 % CI, 0.46–0.94).”
Eldecalcitol is more effective for the prevention of osteoporotic fractures than alfacalcidol“Expert opinion: Eldecalcitol reduced wrist fractures much greater than alfacalcidol and one of the reasons may be a stronger effect of eldecalcitol on preventing falls.”
“This is because eldecalcitol inhibits vitamin D activation in the kidney.”
“These results suggest that the treatment with ELD after ALF significantly suppressed bone turnover and increased L-BMD.”
“The increases in lumbar and hip BMD by eldecalcitol were significantly higher in all tertiles than those by alfacalcidol.”
“ Eldecalcitol [ED-71, 2beta-(3-hydroxypropyloxy)-1,25-dihydroxyvitamin D3] increases lumbar and hip bone mineral density (BMD) in a dose-dependent manner in osteoporotic patients with vitamin D supplementation.”
“In both the lumbar spine and the femur, ELD and ALF monotherapy significantly increased the BMD, and ELD+ALN and ALF+ALN significantly increased the BMD, compared with ALN monotherapy, as an additive effect.”
“On mechanical testing of the lumbar spine, ELD and ALF monotherapy significantly increased the ultimate load, and ELD+ALN and ALF+ALN significantly increased the ultimate load compared with ALN monotherapy.”
Effects of combined treatment with eldecalcitol and alendronate on bone mass, mechanical properties, and bone histomorphometry in ovariectomized rats: a comparison with alfacalcidol and alendronate.
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