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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“BackgroundIt was reported that antiretroviral drugs such as efavirenz can increase the catabolism of vitamin D in HIV infected individuals.”
Effects of vitamin D supplementation on the bone specific biomarkers in HIV infected individuals under treatment with efavirenz“ Efavirenz use can negatively influence vitamin D levels and supplementation is necessary as a likely adjunct to improving CD4+ T cells, resulting in greater effectiveness of the treatment.”
“HIV and/or antiretroviral therapy (ART), particularly efavirenz (EFV), may interfere with vitamin D metabolism.”
“ Efavirenz induces cytochrome P450 enzymes involved in vitamin D metabolism and may accelerate the catabolism of 25-(OH)D and 1,25-(OH)2D3, the latter being the active vitamin D metabolite (26).”
“Initiation of efavirenz (EFV), a nonnucleoside reverse transcriptase inhibitor, is associated with a 6.2- to 12.5-nmol/L decrease in 25-hydroxyvitamin D [25-(OH)D] levels (24, 25).”
“Conclusions Rilpivirine had little effect on 25(OH)D, whereas efavirenz resulted in a significant reduction in 25(OH)D levels and an increase in the risk of severe 25(OH)D deficiency.”
“Results After 48 weeks, mean 25(OH)D levels remained largely unchanged from baseline with rilpivirine (-0.2 ng/ml; P=0.57 versus no change), but were significantly reduced with efavirenz (-2.5 ng/ml; P<0.0001 versus no change).”
“Patients receiving efavirenz had a trend toward lower serum 25(OH)D concentrations (11.1 ± 4.6 ng/mL vs. 14.6 ± 7 ng/mL, P = 0.1).”
“ Efavirenz is associated with a reduction in 25-hydroxy vitamin D levels, tenofovir with secondary hyperparathyroidism, and cART with increased bone turnover and low BMD.”
“Low vitamin D status is common and needs to be assessed among HIV-infected patients including tropical residents especially when EFV is used.”
“Multivariate analysis showed that receiving efavirenz (EFV) was significantly associated with low vitamin D status (odds ratio = 3.60; 95% confidence interval, 1.06-12.15, P <.05).”
“Conclusions ART initiation with EFV is associated with significant decreases in 25(OH)D and an increased risk of hypovitaminosis D compared with non-EFV regimens.”
“Some studies have also shown that efavirenz may cause unfavorable changes in lipid parameters and reductions in vitamin D levels.”
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