Possible Interaction: Vitamin D and Cinacalcet

“Because of the rising trend seen in wPTH, dose of cinacalcet and/or vitamin D need to be modulated.”

“Two weeks after starting treatment with cinacalcet when doses of vitamin D analogues, phosphate binders, and cinacalcet remained unchanged, there was a statistically significant association (p < 0.0001) between the decreases from baseline in PTH and phosphorus.”

“Moreover, the introduction of non-calcium-based phosphate binders (sevelamer and lanthanum carbonate) and cinacalcet (an allosteric activator of the calcium receptor that reduces PTH and the serum calciumxphosphate product) may reduce the risk of hypercalcemia with vitamin D therapy.”

“Compared with … of cinacalcet … vitamin D significantly lowered serum calcium (MD − 0.82, 95% CI − 1.02 to − 0.61, P < 0.001), phosphorus (MD − 0.57, 95% ….18, P = 0.005), and calcium × phosphorus product (MD − 9.41, 95% CI − 10.00 to − 8.82, P < 0.001).”

“Currently, both cinacalcet and vitamin D are used to treat SHPT via two different mechanisms, but it is still unclear whether the combination use of these two drugs can be a safe and effective alternative to vitamin D alone.”

“In comparison with … use of cinacalcet … vitamin D significantly lowered serum calcium, phosphorus, and the calcium × phosphorus product, and did not increase the risk of all adverse events, all-… spasms, and headache, whereas had no effect on serum PTH and increased the risk of hypocalcemia and nausea or vomiting.”

“We altered the CAPD fluids in Physioneal 40 (with a calcium level of 1.25 instead of 1.75 mmol/l), added an extra exchange of Nutrineal in the evening, replaced calcium acetate by lanthanum carbonate, started with cinacalcet and lowered the dose of alfacalcidol.”

“Prescriptions of intravenous vitamin D analogs and cinacalcet increased and parathyroidectomy rates decreased in all regions over time.”

“The added cost of cinacalcet was more significant than the other drugs, including vitamin D and phosphate binders, but the cost was minimal in comparison with the whole dialysis bill.”

“Subjects with aortic valve calcification who were treated with cinacalcet and low doses of vitamin D experienced less progression of CAC than subjects given larger, varying doses of vitamin D (adjusted OR: 0.26; 95% CI: 0.10, 0.64).”

“Treatment with cinacalcet combined with low doses of vitamin D slowed the progression of CAC compared to therapy using larger, varying doses of vitamin D.”

“Moreover, the doses of cinacalcet should be minimized by administering inexpensive vitamin D concomitantly.”

“Moreover, the doses of cinacalcet should be minimized by administering inexpensive vitamin D concomitantly.”