Vertebral spine osteoporosis treatment efficacy in local population: A clinical study.

There is reduction in T-score on supplementation with

Effect of calcium phosphate and vitamin D3 supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron

ResultsAfter four and eight weeks, CaP and CaP +

 supplementations increased faecal excretion of 

 and phosphorus significantly compared to placebo.

Calcium and vitamin D supplementation and risk of kidney stone formation in postmenopausal women.

However, there is a controversial debate on the association between the intake of

 supplements and the increased risk of formation of kidney calculi in postmenopausal women.

Bone metabolism in patients with primary hyperparathyroidism before and after surgery.

Patients who needed postoperative supplementation with

Diet induced thermogenesis, fat oxidation and food intake following sequential meals: influence of calcium and vitamin D.

take at a breakfast meal acutely increased postprandial FOR and DIT over two successive meals, and reduced spontaneous energy intake in the subsequent 24 h period.

Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: a pilot study.

 is the critical hormone for intestinal absorption of 

Effects of Alendronate on bone mass in women with osteoporosis.

, a significant increase of bone mass was established as well: by 2.9% after a year, but the values declined back to the baseline after the second year.

Effects of raloxifene on changes in bone density.

 led to an increase in BMD in 58% examinees at the spine, in 56% at the hip and in 38% at the forearm, which was significantly lower than in women using raloxifene.

The association of calcium and vitamin D with risk of colorectal adenomas.

This trial cohort provides some evidence that

 may be inversely associated with adenoma recurrence.

Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast Density

In multivariate linear regression, simultaneous increments in daily total intakes of 400 IU

 were associated with an 8.5% (95% confidence interval, 1.8-15.1) lower mean breast density.

Estrogen and/or calcium plus vitamin D increase mandibular bone mass.

 for 3 years had increases in mandibular bone mass (0.74 +/- 0.89%, P<0.002).

Treatment with intermittent calcitriol and calcium reduces bone loss after renal transplantation.

 administration prevents corticosteroid-induced osteoporosis, its use in RT recipients is limited by the risk of hypercalcemia.

Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound.

One hundred percent of patients treated with

 had a densitometric decrease greater than the lowest significant difference.

Effects of Vitamin D and Calcium Supplementation on Falls: A Randomized Controlled Trial

 over a 3‐month period reduced the risk of falling by 49% compared with calcium alone.

Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency.

In conclusion, bone mass in older women with vitamin D deficiency increases significantly at the lumbar spine, femur, trochanter, and whole body after

 supplementation for 1 year, and concomitantly bone markers improved as vitamin D levels returned to normal.

The Skeletal Response to Teriparatide Is Largely Independent of Age, Initial Bone Mineral Density, and Prevalent Vertebral Fractures in Postmenopausal Women With Osteoporosis

), there was an inverse relationship between baseline vertebral bone mineral density and vertebral fracture risk.

Can Vitamin D Supplementation Reduce the Risk of Fracture in the Elderly? A Randomized Controlled Trial

Randomized controlled trials have shown that a combination of

 can prevent fragility fractures in the elderly.

Whether this effect is attributed to the combination of

 or to one of these nutrients alone is not known.

Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D.

 may have an important role in determining the effects of 

 on colorectal epithelial proliferation and may explain some of the discrepancies found previously in studies that examine the direct role of calcium on the colorectal epithelium.

Combined Calcium and Vitamin D3 Supplementation in Elderly Women: Confirmation of Reversal of Secondary Hyperparathyroidism and Hip Fracture Risk: The Decalyos II Study

Thus, these data are in agreement with those of Decalyos I and indicate that

 in combination reverse senile secondary hyperparathyroidism and reduce both hip bone loss and the risk of hip fracture in elderly institutionalized women.

Influence of Daily Regimen Calcium and Vitamin D Supplementation on Parathyroid Hormone Secretion

 supplementation, a statistically significant decrease in serum PTH was observed with both regimens, compared with baseline and with the control procedure.

We therefore conclude that the administration … doses of 500 mg of

 6 hours apart provides a more prolonged decrease in serum PTH levels than the administration of the … total amount of Ca and vitamin D as a single morning dose in young healthy volunteers.

Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy?

 may further reduce the rate of PO hypocalcemia, without inhibiting parathyroid hormone secretion.

Long-term effects of nutrient intervention on markers of bone remodeling and calciotropic hormones in late-postmenopausal women.

 reduce bone loss and fracture risk in the elderly.

Influence of daily calcium and vitamin D supplementation on parathyroid hormone secretion

We therefore conclude that the … administration of 500 mg

 at 6-hour intervals provides a more prolonged decrease in serum parathyroid hormone levels than the administration of … same total amount of calcium and vitamin D ,as a single morning dose in young healthy volunteers.

Rapid suppression of S-PTH by oral calcitriol and calcium in healthy premenopausal women.

 increased significantly after calcium plus 1,25(OH)2 vitamin D3 (p<0.01) and calcium plus 

 (p<0.05) compared to the control period.

A Randomized Controlled Trial of Vitamin D Supplementation on Preventing Postmenopausal Bone Loss and Modifying Bone Metabolism Using Identical Twin Pairs

, has been shown to increase bone mineral density (BMD) and reduce the incidence of hip fracture in elderly subjects.

Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full‐time care

 increases BMD in children with the most severe form of CP, who are receiving antiepileptic drugs.

The roles of calcium and vitamin D in the prevention of osteoporosis.

Some of the most substantial reductions in fracture rates have been found with combined therapy with

, and in these protocols it is not clear which is the principal active agent or whether, in fact, the combination is necessary for optimal antifracture efficacy.

Calcium and Vitamin D3 Supplementation Prevents Bone Loss in the Spine Secondary to Low-Dose Corticosteroids in Patients with Rheumatoid Arthritis

Although study groups were similar for most characteristics, the patients receiving

 tended to have disease of greater severity (by radiologic stage) and longer duration than did those receiving placebo.

Effect of 24,25-dihydroxycholecalciferol on intestinal absorption of calcium and phosphate and on parathyroid hormone secretion in chronic renal failure.

 was associated with small but significant increments … the fractional rates of absorption of 

 (p less than 0.01) and phosphate (p less than 0.05) measured by a … radioisotope test, but even during treatment, the absorption of both calcium and phosphate remained subnormal.

Controlled trial of the effects of 1,25-dihydroxycholecalciferol in patients treated with regular dialysis.

 (p less than .05) but not in those on 1,25(OH)2D3.

1,25 dihydroxycholecalciferol effects in chronic dialysis. A double-blind controlled study.

 (p less than 0.05) but not in those on 1,25(OH)2D3.

[Oral application of calcium and vitamin D2 in allergic bronchial asthma (author's transl)].

, causes a decrease of airway obstruction in patients with allergic bronchial asthma.

Effect of calcium and cholecalciferol supplementation on several parameters of calcium status in plasma and urine of captive Asian (Elephas maximus) and African elephants (Loxodonta africana).

Preliminary findings indicate that the advisable permanent daily intake for

 in both elephant species at least during winter might be higher than current guidelines.

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial

Our subanalysis also revealed that the bone‐protective benefit of resveratrol was greater in participants who supplemented with

Vitamin D3 action within the ovary - an updated review.

Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk?

Adding to this complexity is the fact that many adults take

 together for bone health, and there is some concern (albeit inconclusive) related to calcium use and increased CVD risk.

Vitamin D and the skin: what should a dermatologist know?

 and phosphorus absorption; however, the actions of vitamin D are not confined to bone.

Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension.

, as a natural medicine, is known to regulate 

Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

Epidemiological studies suggest an inverse correlation between

 intake and the risk of colorectal cancer (CRC).

PTH and Vitamin D.

 and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation.

[Vitamin D3 and Male Reproduction].

 and phosphorus metabolic balance and maintaining bone health in vivo.

Is vitamin D the answer for prevention of uterine fibroids?

Vitamin D deficiency is defined as a serum level of 25(OH)D below …/L), with a normal level equaling >30 ng/mL. It is well established that

 plays an integral part … increases the absorption of 

 and phosphorous, decreasing the incidence … falls secondary to muscle weakness.

The renin–angiotensin–aldosterone system and calcium-regulatory hormones

Specifically, we review studies describing the inhibition of renin activity by

, and a potentially bidirectional and stimulatory relationship between aldosterone and parathyroid hormone.

Vitamin D signaling in calcium and bone homeostasis: a delicate balance.

 supplements is still debated and requires further investigation.

Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress.

 (Ca2+) and phosphorus uptake and transport, but also correlates with neurocognitive decline and neurodegenerative diseases.

The role of vitamin D in melanogenesis with an emphasis on vitiligo.

 and bone metabolism, controls cell proliferation and differentiation, and exerts immunoregulatory activities.

The impact of paricalcitol on left ventricular hypertrophy.

Vitamin D treatment in primary hyperparathyroidism.

However, some patients experience increasing plasma or urine levels of

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101).Conclusion:We found an inverse association between

 intake and cervical neoplasia risk among a group of Japanese women.

Bone morphogenetic protein-7 inhibits vascular calcification induced by high vitamin D in mice.

 in thoracic aortas and hearts and the expression levels of osteopontin and osteocalcin in mice.

A new role for vitamin D receptor activation in chronic kidney disease.

 has proven to be much more than a simple "

Milk Products, Insulin Resistance Syndrome and Type 2 Diabetes

A growing body of evidence suggests an inverse relationship between

 status and dairy food intake and the development of the insulin resistance syndrome (IRS) and type 2 diabetes mellitus (t2DM).

The role of calcium and vitamin D in the management of osteoporosis.

 may be beneficial in terms of efficacy and, perhaps, for optimising adherence.

[The pleiotropic effects of vitamin D on kidney disease].

 is well known to play major roles in maintenance of 

Calcium, vitamin D and the vitamin D receptor: impact on prostate and breast cancer in preclinical models.

, another nutrient that has been associated with cancer risk in epidemiological studies.

Vitamin D and colon carcinogenesis.

Because of the apparent synergistic effect of

, cosupplementation of both nutrients in cancer prevention programs may be advised.

Genetic control of susceptibility to osteoporosis.

Polymorphisms of vitamin D receptor have been associated with bone mass in several studies, and there is evidence to suggest that this association may be modified by

Dietary considerations to prevent loss of bone and renal function.

Nevertheless, a growing number of studies support the importance of adequate intakes of both

, particularly in the elderly, to maintain bone mass.

Fish consumption, cancer, and Alzheimer disease.

The hypothesis proposed to explain the link between calcium and prostate cancer is that

 (5), which has been shown to inhibit prostate cancer cell growth (6).

Preclinical and Early Human Studies of Calcium and Colon Cancer Prevention

Many experimental findings described below have indicated associations between high

 intake and decreased risk for colorectal cancer.

The Advantage of Alfacalcidol Over Vitamin D in the Treatment of Osteoporosis

 (Ca) absorption, increases urinary Ca excretion and serum Ca levels, and suppresses parathyroid hormone (PTH) secretion.

[Immune modulation by vitamin D analogs in the prevention of autoimmune diseases].

 and phosphate and is an essential link in bone resorption and formation and calcium metabolism.

[Bladder replacement and continent diversion: what about metabolic complications?].

Furthermore, there may be a malabsorption of

 with development of intestinal osteopathy due to the reduction of absorptive surface.

The vitamin D endocrine system, calcium metabolism, and osteoporosis.

, periodic monitoring of blood and urine calcium is necessary to avoid hypercalcemia and hypercalciuria.

Metabolism, function and clinical aspects of vitamin D.

Certainly the most accepted major action of

 is to enhance the intestinal absorption of 

Vitamin D3 and absorption of calcium in the chick.

Although it has been known for many years that

, the exact biochemical mechanism of its action is still not clear.

Calcium absorption and vitamin D in the chick.

 within the first halfhour after the administration of calcium.

[Postoperative hypocalcemia - the most common complication of endocrine head and neck surgery: acute management].

 can mitigate or prevent the postoperative drop of calcium levels.

Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis

The results of this meta-analysis study indicates that vitamin D may be considered an adiponectin secretagogue in subjects with diabetes and this effect may be potentiated if

 intake is on daily basis and in combination with 

Data Mining: Biological and temporal factors associated with blood parathyroid hormone, vitamin D, and calcium concentrations in the Southwestern Chinese population.

Dietary patterns and hip fracture in the Adventist Health Study 2: combined vitamin D and calcium supplementation mitigate increased hip fracture risk among vegans.

Fracture risk varied according to dietary pattern, with a clear effect modification by concurrent supplementation with both

No effect of calcium and vitamin D intake on maternal blood pressure in a healthy pregnant population.

OBJECTIVES Clinical studies have reported an inverse relationship between

 intake and hypertensive disorders of pregnancy (HDP).

Novel Phototherapy Kiosk Shows Promise as a Treatment Option for Low Vitamin D.

 was well below the recommended daily allowance for each nutrient, and group.

Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet

 and phosphorus metabolism, also influencing bone tissue.

Vitamin D and Stress Fractures in Sport: Preventive and Therapeutic Measures—A Narrative Review

In case of a deficiency of 25(OH)D, normal blood levels of ≥30 ng/mL may be restored by optimizing the athlete’… 25(OH)D. Very recent studies suggested that the prevalence of stress fractures decreased when athletes are supplemented daily with 800 IU

Vitamin D for Growth and Rickets in Stunted Children: A Randomized Trial

The mean difference in height-for-age z score was 0.05 (95% CI: −0.05 to 0.15), P = .3, although the effect of

 was greater for those consuming >300 mg/day of 

Vitamin D Status in Patients with Atrial Fibrillation and Heart Failure - Is there a Link?

A systematic review and meta-analysis of vitamin D and calcium in preventing osteoporotic fractures

This systematic review suggests that the combination of

 can exert a beneficial effect towards osteoporotic fracture reduction.

Association between vitamin D/calcium intake and 25-hydroxyvitamin D and risk of ovarian cancer: a dose-response relationship meta-analysis

 was not effective for the prevention of ovarian cancer (p = 0.98).

Bone Health

 is critical for bone development because it facilitates the active absorption of 

Early-Life Effects of Vitamin D: A Focus on Pregnancy and Lactation

Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

 significantly increased femoral neck BMD only when the dose of the vitamin D intake was no more than 400 IU d-1 (SMD = … IU d-1 (SMD = -0.098; 95% CI: -0.109 to 0.305), and calcium had no effect on the femoral neck BMD.

Non-pregnant Women Have a Lower Vitamin D than Pregnant Women After Gastric Bypass

It also encourages further investigation on the number of pregnancies/deliveries during prenatal care, due to

, and it points out that changes in concentrations of this vitamin in pregnant women may lead to SGA/LGA newborns’ births.

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Possible Interaction: Vitamin D and Calcium Supplement

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Research Papers that Mention the Interaction