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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin D
drug:
Alitretinoin
Research Papers that Mention the Interaction
“Cellular studies have revealed that combinations of vitamin D derivatives and retinoids such as ATRA and 9-cis retinoic acid (9-cis RA) exhibit cooperative effects on differentiation in established leukemia cell lines such as HL-60, U937, and NB4.”
Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D.“The association of 9-cis-retinoic acid , the ligand of RXR, with vitamin D3 derivatives modified the demonstrated effects, indicating in our model, a preferential effect of vitamin D3 derivatives via the heterodimeric form of the receptor.”
“Hence, certain combinations of signals, elicited by 9-cis RA and D3 , promote apoptosis of HL60 cells.”
“The observed cooperativities between either 9-cis RA or all-trans RA and D3 have important implications for the use of combinations of these agents in differentiation therapy.”
“In cultured keratinocytes, 9-cis retinoic acid (9cRA), a panagonist for RXR and retinoic acid receptor (RAR), and an RXR-selective agonist, SR11237, synergized with D3 to activate DR3 via endogenous as well as overexpressed VDR-RXR, whereas both of these RXR agonists alone were ineffective.”
Retinoid X receptor-specific ligands synergistically upregulate 1, 25-dihydroxyvitamin D3-dependent transcription in epidermal keratinocytes in vitro and in vivo.
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